Evidence before you spend
Is it worth it after 40?
Evidence-based answers for women 40+ navigating health, menopause, beauty, supplements, fitness, and healthy aging.
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Explore the evidence
Skin & Beauty
Evidence on skincare, cosmetic treatments, devices, and ingredients for skin health, appearance, and visible signs of aging.
Hair & Scalp
Evidence on hair growth, thinning, hair-loss treatments, scalp approaches, and products marketed for healthier or fuller hair.
Hormones & Menopause
Evidence on menopause symptoms, systemic hormone therapies, and supplements or treatments marketed for hormonal concerns.
Sexual & Intimate Health
Evidence on treatments and approaches for vaginal, sexual, and intimate-health concerns in midlife and beyond.
Supplements & Nutrition
Evidence on supplements, nutrients, powders, and nutrition-related products marketed for health and healthy aging.
Fitness & Strength
Evidence on exercise, strength, body-support products, and fitness approaches for maintaining function and physical health.
Sleep & Stress
Evidence on sleep, circadian health, light exposure, stress, and approaches marketed for better rest and recovery.
Heart & Bone Health
Evidence on products, treatments, and lifestyle approaches related to cardiovascular and bone health.
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Skin & Beauty
Topical Retinoids: Retinol vs Tretinoin
Prescription tretinoin has strong evidence for improving signs of sun-damaged skin, including fine wrinkles and uneven pigmentation. OTC retinol may help too, but its evidence is less extensive and products vary considerably.
Supplements & Nutrition
Creatine Monohydrate for Women 40+
One of the better-studied supplements for strength and muscle, but some popular midlife claims go beyond the evidence.